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  • Title: The effect of gastric antigens on the in vitro migration of leucocytes from patients with atrophic gastritis and pernicious anaemia.
    Author: Goldstone AH, Calder EA, Barnes EW, Irvine WJ.
    Journal: Clin Exp Immunol; 1973 Aug; 14(4):501-8. PubMed ID: 4747581.
    Abstract:
    A total of eighteen patients with pernicious anaemia (PA) ten patients with atrophic gastritis and achlorhydria but without PA, and fourteen control subjects were tested for delayed hypersensitivity to gastric antigens using the leucocyte migration test. The percentage of PAs showing inhibition of migration in the presence of a crude extract of gastric mucosa, liver mitochondria, stomach mitochondria and stomach microsomes was 50, 55, 50 and 50% respectively. The results in atrophic gastritis were 0, 20, 20 and 0% respectively and those in the fourteen control subjects were 0, 14, 7 and 14% respectively. There was a significant difference between PA and controls with all four antigens. There was a significant difference using crude extract and stomach mitochondria and microsomes between PA and atrophic gastritis but not with liver mitochondria. There was no significant difference between atrophic gastritis and controls although the results tended to be midway between PA values and controls. These results indicate that cell-mediated immunity is more strongly implicated in PA than it is in atrophic gastritis which has not progressed to PA.
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