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  • Title: Premature menarche without other evidence of precocious puberty.
    Author: Heller ME, Dewhurst J, Grant DB.
    Journal: Arch Dis Child; 1979 Jun; 54(6):472-5. PubMed ID: 475434.
    Abstract:
    We describe 4 young girls with recurrent vaginal bleeding in the absence of other signs of precocious sexual development. Investigation showed low oestrogen levels in 2 of them, and basal gonadotrophins were in the upper part of the prepubertal range. We believe that the isolated early menstruation in these patients was possibly related to increased sensitivity of the endometrium to oestrogens.
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