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  • Title: Biosynthesis of a 7-alpha-methoxycephalosporin. Incorporation of molecular oxygen.
    Author: O'Sullivan J, Aplin RT, Stevens CM, Abraham EP.
    Journal: Biochem J; 1979 Apr 01; 179(1):47-52. PubMed ID: 475760.
    Abstract:
    A 7-alpha-methoxycephalosporin containing a carbamoyloxymethyl substituent at C-3 (cephamycin C) has been isolated from the extracellular fluid of an aqueous suspension of Streptomyces clavuligerus shaken in the presence of 18O2. The cephalosporin has been converted into its N-acetyl dimethyl ester and the distribution of 18O in the latter determined by chemical-ionization mass spectrometry. The results indicate that the oxygen atom of the methoxy group, as well as that linked to the exocyclic methylene group at C-3, is derived from molecular O2.
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