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  • Title: [Malignant, rapidly progressing nephritis in Schönlein-Henoch disease].
    Author: Karastanev I, Dimitrakov D, Kostov K, Goranov S.
    Journal: Vutr Boles; 1979; 18(3):229-34. PubMed ID: 475902.
    Abstract:
    A case of malignant quickly progressing Henoch-nephritis is described, with a lethal end one and a half month after the initial manifestations. The disease develops with a clinical picture typical for systemic vasculitis, with joint-pain, skin-rash and grave abdominal syndrome, being the reason for unnecessary surgical intervention. The renal changes originate even at the very beginning of the disease and are clinically characterized, besides the exceptionally quick evolution, by the picture of acute renal insufficiency with progressing azotemia, severe electrolyte disturbances and anemic syndrome and pathomorphologically by the picture of severe diffuse intra- and extracapillary proliferative glomerulitis. The treatment with antihistamine preparations, heparin and corticosteroids failed to give an effect.
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