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  • Title: Linoleic acid hydroperoxide: impaired bacterial uptake by alveolar macrophages, a mechanism of oxidant lung injury.
    Author: Khandwala A, Gee JB.
    Journal: Science; 1973 Dec 28; 182(4119):1364-5. PubMed ID: 4760314.
    Abstract:
    Exogenous linoleic acid hydroperoxide causes in vitro impairment of both bacterial uptake and the phagocytic stimulation of (14)CO(2) production from [1-(14)C]glucose in rabbit alveolar macrophages by an undefined effect on the cell membrane. This effect may be one mechanism for the defective pulmonary bacterial clearance characteristic of oxidant lung injury.
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