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  • Title: Sodium gradient dependence of proline and glycine uptake in rat renal brush-border membrane vesicles.
    Author: McNamara PD, Pepe LM, Segal S.
    Journal: Biochim Biophys Acta; 1979 Sep 04; 556(1):151-60. PubMed ID: 476115.
    Abstract:
    The sodium-dependent entry of proline and glycine into rat renal brush-border membrane vesicles was examined. The high Km system for proline shows no sodium dependence. The low Km system for glycine entry is strictly dependent on a Na+ gradient but shows no evidence of the carrier system having any affinity for Na+. The low Km system for proline and high Km system for glycine transport appear to be shared. Both systems are stimulated by a Na+ gradient and appear to have an affinity for the Na+. The effect of decreasing the Na+ concentration in the ionic gradient is to alter the Km for amino acid entry and, at low Na+ concentrations, to inhibit the V for glycine entry.
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