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  • Title: Effects of hydrocortisone treatment and whole body irradiation on mouse lymphocyte stimulation in vitro.
    Author: Rühl H, Vogt W, Rühl U, Bochert G, Schmidt S.
    Journal: Immunology; 1973 Nov; 25(5):753-60. PubMed ID: 4761631.
    Abstract:
    Whole body irradiation was found to reduce the number of nucleated cells in the thymus and the spleen of C57B1 mice to the same extent as hydrocortisone treatment. Equal numbers of thymus and spleen cells from either hydrocortisone-treated or irradiated mice and matched controls were cultured and stimulated with various mitogens. An increased stimulation of DNA synthesis by PHA, Con A and PWM was found in thymus and spleen cells after hydrocortisone treatment as well as after whole body irradiation. In contrast, the response to LPS, known as a typical B-cell mitogen, was not affected by any of the procedures.
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