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  • Title: [Gonadotoxic action of acetylsalicylic acid].
    Author: Vasilenko NM, Manzhelaĭ ES, Gnezdilova AI.
    Journal: Farmakol Toksikol; 1979; 42(4):421-3. PubMed ID: 477965.
    Abstract:
    It has been established in experiments on white rats that administration of acetylsalicylic acid (ASA) in a dose of 1/10 LD50 for 1 1/2 months is accompanied by a decrease in the functional activity of spermatozoids. Repeated inhalation of ASA dust at a concentration of 25 mg/m3 for 4 months produces morphological changes in the spermatogenic epithelium and abnormal antenatal development of the progeny of male animals under test.
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