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  • Title: Cell-mediated immunity to moloney sarcoma virus in mice. I. Analysis of antigens responsible for lymphocyte stimulation in regressor mice.
    Author: Knight RA, Gorczynski RM.
    Journal: Int J Cancer; 1975 Jan 15; 15(1):48-58. PubMed ID: 47841.
    Abstract:
    Purified viruses, viral antigens, and cell extracts have been tested for their ability to stimulate protein synthesis by MSV-M-1 regressor spleen cells from BALB/c mice. Immune, but not normal cells, responded to MSV-M, but not to MSV-G virus-1, and to the type-specific viral envelope glycoprotein from MSV-M virus. Extracts of mouse embryo fibroblasts transformed by either MSV-M or MSV-G, however, specifically stimulated MSV-M regressor spleen cells. Cells stimulated by different antigens, and by phytohaemagglutinin, had the same sedimentation profile and were identified as T-lymphocytes.
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