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  • Title: Hepatotoxicity due to pemoline. Report of two cases.
    Author: Tolman KG, Freston JW, Berenson MM, Sannella JJ.
    Journal: Digestion; 1973; 9(6):532-9. PubMed ID: 4787851.
    Abstract:
    Pemoline, a central nervous system stimulant, has been used extensively in Great Britain and Europe for a variety of conditions including memory failure and depression. In the 10 years that the drug has been used no report of hepatotoxicity has appeared. A prospective study of efficacy and safety of pemoline was started in the United States approximately 3 years ago. This report describes two patients who developed reversible liver abnormalities while receiving pemoline during the study and following rechallenge with the drug.
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