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  • Title: Comparison of radioimmunoassay and counterimmunoelectrophoresis for the detection of hepatitis B surface antigen carriers in a high-prevalence region.
    Author: Sandler SG, Knecht A, Amar A, Davidowitch R.
    Journal: Isr J Med Sci; 1979 Jul; 15(7):579-82. PubMed ID: 478821.
    Abstract:
    Solid-phase radioimmunoassay (RIA) and counterimmunoelectrophoresis (CIE) were compared for the detection of hepatitis B surface antigen (HBsAg) carriers among blood donors in Jerusalem, which is in a region characterized by a high prevalence of HBsAg and a predominance of the ayw subtype. RIA detected 84% more HBsAg carriers than CIE, with the resultant exclusion of 1.8 times as many potentially infective donors. The results provide additional information concerning the specific increases in donor-carrier detection that are associated with the introduction of highly sensitive HBsAg tests in different geographic and epidemiologic circumstances.
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