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  • Title: Effect of some non-steroidal antifertility agents on biochemistry of the uterus and uterine fluid in rats.
    Author: Kamboj VP, Singh MM, Kar AB.
    Journal: Indian J Exp Biol; 1973 Nov; 11(6):479-83. PubMed ID: 4792741.
    Abstract:
    The effect of 3 postcoital antifertility agents (4 and 20 mg/kg DBF, 2 and 10 mg/kg NF, and .25 and 1.25 mg/kg Centchroman) on histology and biochemistry of the uterus and uterine fluid of mated rats was investigated. The low and high doses of all the compounds showed, in general, estrogenic type histologic changes. They generally caused an increase in uterine dry matter, protein, RNA, glycogen, and alkaline phosphatase, and a decrease in wet weight, nonprotein nitrogen, and acid phosphatase (p.01). In uterine fluid, alkaline phosphatase was markedly stimulated after high dosages of DBF and NF and low dosages of Centchroman (p.01). .25 mg Centchroman possessed estrogenic activity, whereas 1.25 mg showed antiestrogenicity. The compounds appeared to interfere with the action of both estrogen and progesterone in varying degrees.
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