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  • Title: The one-point method in predicting dosage regimen in case of hepatic and/or renal failure in presence or absence of change in volume of distribution.
    Author: Ritschel WA, Thompson GA.
    Journal: J Clin Pharmacol; 1979 Jul; 19(7):350-6. PubMed ID: 479379.
    Abstract:
    In some clinical situations such as in acute myocardial or coronary infarction, liver disease, renal failure, hypoalbuminemia, displacement from protein binding, etc., both the volume of distribution and the elimination rate may change. The determination of the creatinine clearance may be too time consuming, and the serum creatinine concentration may be an unreliable indicator in some cases (acute renal failure, uremia, muscular diseases, old age, etc). Neither indicates change in elimination by extrarenal routes (metabolism in liver disease). The "repeated one-point method" is presented as clinical tool to calculate the dosage regimen for patients where differences in Vd and kel can be expected. The method is based on the evaluation of one blood sample each in the first two dosing intervals after administration of a test dose. The "repeated one-point method" is compared with the previously published "one-point method."
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