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  • Title: Synthesis of substituted 2-aminopyrrole analogs of lidocaine II.
    Author: Johnson RW, Keenan TH, Kosh JW, Sowell JW.
    Journal: J Pharm Sci; 1979 Aug; 68(8):955-8. PubMed ID: 480174.
    Abstract:
    The synthesis and local anesthetic and antiarrhythmic properties of eight substituted 2-diethylaminoacetamido-3-carbamyl-4-methylpyrroles are described. Three compounds showed significant local anesthetic activity by the guinea pig wheal test, and four showed antiarrhythmic activity against chloroform-induced ventricular arrhythmias in mice.
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