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  • Title: Antifertility effect of sympathomimetic drugs on male rats when applied locally to the vas deferens.
    Author: Ratnasooriya WD, Gilmore DP, Wadsworth RM.
    Journal: J Reprod Fertil; 1979 Jul; 56(2):643-51. PubMed ID: 480316.
    Abstract:
    Local application of collars containing 25% methoxamine, 50% or 75% tyramine or 50% norephedrine to both vasa deferentia of rats caused a reduction in fertility but not in their ability to mate. A gradual return to fertility was seen in those animals which received the lower dose of tyramine or norephedrine, while the other treatments caused a permanent reduction in fertility. The cause of sterility was production of azoospermic ejaculates resulting from either a block in sperm transport in the vas deferens or from a deficiency in the ejaculatory mechanism. Only methoxamine caused a mechanical obstruction of the vas deferens, but it is possible that the other drugs caused a sustained spasm. An emission defect could have been due to transmitter depletion, receptor-specific desensitization or presynaptic alpha-adrenoreceptor-mediated inhibition. Spermatozoa from the cauda epididymidis were immotile following the treatments.
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