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  • Title: [Complete molar abortion induced with prostaglandin F2 alpha].
    Author: Herrera M, Leyton H.
    Journal: Rev Chil Obstet Ginecol; 1973; 38(3):146-9. PubMed ID: 4803559.
    Abstract:
    Prostaglandins (PGs) are unsaturated fatty acids with 20 carbon atoms; they are to be found in most human and animal tissues. There are 13 known PGs divided into 4 groups, E, F, A, and B. This article describes the use of PGF2alpha in a case of missed abortion. The patient, aged 22, was 9 months pregnant according to the date of last menstruation; the abdominal examination revealed uterine size corresponding to a 3 months' pregnancy; no fetal cardiac sign was present. Intravenous infusion of PGF2alpha was started with a dose of 25 mcg/minute for the first 30 minutes, then at a dose of 50 mcg/minute. Contractions started 1 hour 35 minutes after infusion, and continued irregularly. The patient aborted suddenly and completely at 10 hours 25 minutes after beginning of infusion; total quantity of PGF2alpha used was of 35 mg. A series of unpleasant side effects accompanied the procedure, starting at about 2 hours 10 minutes after starting PG infusion, precardial pain, nausea and vomiting; there was no diarrhea. The mechanism of PGs in inducing abortion is still unknown; administration can be intrauterine, besides intravenous, and, apparently, PGE1 is much more powerful than PGF2alpha.
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