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  • Title: Promotional effect of sodium barbiturate on intestinal tumors induced in rats by dimethylhydrazine.
    Author: Pollard M, Luckert PH.
    Journal: J Natl Cancer Inst; 1979 Oct; 63(4):1089-92. PubMed ID: 480382.
    Abstract:
    Noninbred Sprague-Dawley rats were administered 1,2-dimethylhydrazine hydrochloride (DMH) by gavage or methylazoxymethanol acetate by sc inoculation. Thereafter, one group was given water to which 0.1% sodium barbiturate was added, and the other was given drug-free water. They were examined 20 weeks after onset of the experiments. A direct relationship was noted between dosage of DMH and numbers of intestinal tumors induced in the rats. The rats provided with sodium barbiturate-supplemented water developed more intestinal tumors than did those that drank drug-free water.
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