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  • Title: Jaundice after repeated exposure to halothane: an analysis of Reports to the Committee on Safety of Medicines.
    Author: Inman WH, Mushin WW.
    Journal: Br Med J; 1974 Jan 05; 1(5896):5-10. PubMed ID: 4808831.
    Abstract:
    Analysis of data derived from 130 reports of jaundice occurring after anaesthesia with halothane showed a significant relation between the number of exposures to this anaesthetic and the rapidity with which jaundice develops after exposure. This is considered to provide strong evidence of a cause-effect relationship between the use of halothane and jaundice. Out of 114 patients with complete anaesthetic histories 94 (82%) had been exposed more than once; of those so exposed 80% had been anaesthetized with halothane more than once within 28 days. Altogether 66 (51%) of the 130 patients died.
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