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  • Title: Amphetamine in human plasma: a sensitive and specific enzymatic assay.
    Author: Kreuz DS, Axelrod J.
    Journal: Science; 1974 Feb 01; 183(4123):420-1. PubMed ID: 4808972.
    Abstract:
    A sensitive and specific enzymatic-isotopic method of determining plasma amphetamine concentrations in man is described. The assay is based on the transfer of the tritiated methyl group of S-adenosyl-L-[methyl-(3)H]methionine to amphetamine in the presence of a partially purified N-methyltransferase from rabbit lung. With this assay as little as 10 nanograms of amphetamine per milliliter of plasma can be accurately determined. The concentrations of d- and 1-amphetamine in the plasma after 20 to 30 milligrams of the drug had been ingested by human subjects are reported.
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