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  • Title: Platelets and platelet function in patients with chronic uremia on maintenance hemodialysis.
    Author: Jørgensen KA, Ingeberg S.
    Journal: Nephron; 1979; 23(5):233-6. PubMed ID: 481658.
    Abstract:
    In 20 chronic uremic patients on maintenance hemodialysis, who were not taking any medication known to affect platelet function, the following investigations were carried out: platelet count, fibrin/fibrinogen degradation products, fibrinogen and plasminogen concentration, platelet adhesiveness, clot retraction and platelet aggregation induced by ADP, ristocetin, fibrinogen, collagen and epinephrine. The only significant abnormal result was a decreased clot retraction. We consider many cases of so-called uremic bleeding to be caused by the medication taken and conclude that on well-controlled hemodialysis treatment, bleeding tendency should not be a major problem.
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