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  • Title: Dissimilar effects of lithium isotopes on motility in rats.
    Author: Lieberman KW, Alexander GJ, Stokes P.
    Journal: Pharmacol Biochem Behav; 1979 Jun; 10(6):933-5. PubMed ID: 482316.
    Abstract:
    Male Wistar rats were injected twice daily with chlorides of pure lithium isotopes, either Li-6 or Li-7. While both salts decreased mobility, the salt of Li-6 initially produced a more profound effect than the salt of Li-7. This differential effect of the isotopes proved to be time dependent and was most evident on the third day of treatment. Li-6 is likely to become a valuable tool in basic psychopharmacological research. It may possess therapeutic and/or toxic properties that are different from those of lithium salts currently used in treatment of mania.
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