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  • Title: Comparative effects of delta 9-tetrahydrocannabinol, tetrabenazine and chlorpromazine on rectal temperature in the rat.
    Author: Diamantis W, Melton J, Sofia RD.
    Journal: Pharmacology; 1979; 18(5):251-6. PubMed ID: 482345.
    Abstract:
    Tetrabenazine evoked a biphasic response in rectal temperature of the rat following intraperitoneal administration of 4.4--70.0 mg/kg. The initial hyperthermia was inversely related to the dose while the subsequent hypothermia was dose-dependent. This biphasic effect on temperature was similar to that seen with THC at 0.5 mg/kg, thus adding further evidence of a similarity in the mode of action of the two drugs. In contrast, only hypothermia was evident following chlorpromazine administration.
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