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  • Title: Evolution of biosynthetic pathways: immunological approach.
    Author: Truffa-Bachi P, Guiso N, Cohen GN, Theze J, Burr B.
    Journal: Proc Natl Acad Sci U S A; 1975 Apr; 72(4):1268-71. PubMed ID: 48255.
    Abstract:
    Through the use of specific immunoadsorbent columns, it is shown that Escherichia coli aspartokinase I-homoserine dehydrogenase I, aspartokinase II-homoserine dehydrogenase II, aspartokinase III, and homoserine kinase, enzymes involved in the same complex biosynthetic pathway, share antigenic determinants. This raises the question of a common origin for the four cibtenoirart kinases. (Aspartate kinase or ATP:L aspartate 4-phosphotransferase, EC 2.7.2.4; homoserine dehydrogenase or Lhomoserine:NADP oxidoreductase, EC 1.1.1.3; homoserine kinase or ATP:L-homoserine O-phosphotransferase, EC 2.7.1.39.)
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