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  • Title: Studies on plasma coagulation and fibrinolysis during oral contraception of various types with special reference to cold activation of factor VII.
    Author: Gjonnaess H, Fagerhol MK.
    Journal: Scand J Haematol; 1974; 12(3):232-40. PubMed ID: 4831827.
    Abstract:
    Selected coagulation and fibrinolytic factors were measured in plasma from 72 women taking oral contraceptives in a longitudinal study. Specific pills and sampling schedules were: Anovlar (3 mg norethisterone acetate and .05 mg ethinyl estradiol, combined), taken by 40 women sampled before, after 1 and 3 weeks, and 1 week of interruption; Sequens (.1 mg mestranol and 1.5 mg chlormadinone acetate sequential), 21 women, sampled before and after 2 and 3 weeks, and after 1 week of interruption; Ro 6-3129 (6-16-ethylthioretroprogesterone, 8-12 mg, continuously), 11 women, sampled after 1 month; additional samples were taken after 2, 3, 5, 7, 9 and 11 months. The pills containing estrogen affected the following parameters of the extrinsic coagulation system: thrombotest increased (p less than .001). Cold activition (20 hours at 0 degrees C.) of factor 7 was positive in 65% of subjects after pills, but 9% before. Estrogen pills decreased cephalin time (p less than .05), a screening test for the intrinsic coagulation system. Factors 8 (p less than .05), IX (p less than .02), and fibrinogen (p less than .001) increased. In the fibrinolytic system the estrogen pills increased plasminogen (p less than .001), proteolytic capacity (p less than .001) and streptokinase activated plasminogen activator (p less than .001). Among proteinase inhibitors, antiplasmin activity (p less than .01), antithrombin 3 (p less than .001) and C'i inactivator (p less than .001) decreased. Progestagen alone, or added in sequentials had no effect. Since the activation of clotting factors is probably more important than increases in concentration of 1 or more factors, the increased cold activition of factor 7 was considered indicative of increased clotting tendency.
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