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  • Title: Endocervical changes with the use of synthetic steroids.
    Author: Mingeot R, Fievez C.
    Journal: Obstet Gynecol; 1974 Jul; 44(1):53-9. PubMed ID: 4834799.
    Abstract:
    Histologic observations of patients who exhibited cervical ectropion and colposcopic changes of vascular congestion and increased mucous secretion were made. 73 cervical biopsies were obtained from patients with normal cycles, and 106 endocervical biopsies were obtained from patients being treated with combined synthetic steroids. 6 of the 73 cervical biopsies showed epidermoid metaplasia of the surface epithelium whereas 21 of the 106 endocervical biopsies showed partial metaplasia of the surface epithelium, a significant difference (p less than .05). 2 of the 106 showed adenomatoid hyperplasia. This study indicated that the changes induced by synthetic steroids when at their maximum are equaled under no other circumstances, even during pregnancy.
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