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  • Title: Effects of ergotamine and methysergide on blood platelet aggregation responses of migrainous subjects.
    Author: Hilton BP, Zilkha KJ.
    Journal: J Neurol Neurosurg Psychiatry; 1974 May; 37(5):593-7. PubMed ID: 4836755.
    Abstract:
    Platelet aggregation responses to 5-hydroxytryptamine (5-HT) were measured in plasma from migrainous subjects taking either methysergide maleate or ergotamine tartrate and were found to be reduced. Blood 5-HT levels of subjects free of headache were not affected by these drugs. The results support the hypothesis that methysergide and ergotamine act by occupying 5-HT uptake sites in vessel walls, leaving 5-HT molecules available to occupy receptors concerned with vasoconstriction.
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