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  • Title: [Properties of viruses isolated from human fibroblasts culture treated by paraganglioma culture filtrate].
    Author: Klenova AV, Borodina NP, Chizhevskaya VI, Eremina LA, Voskoboinik AD, Shevlyagin VY.
    Journal: Vopr Onkol; 1979; 25(9):42-6. PubMed ID: 483718.
    Abstract:
    In the human fibroblasts culture, transformed by the material from malignant paraganglioma culture, there was found the RNA- and DNA containing virus synthesis. The RNA-containing virus with a buoyant density of 1.16--1.18 g/ml shows no hemagglutinating activity, it fails to infect newborn Syrian hamsters, and produces no transformation-destruction changes in mammalian tissue culture. The DNA-containing virus with a buoyant density of 1.24--1.28 g/ml would agglutinate the guinea-pig and group 0 human erythrocytes, produces lesions in newborn Syrian hamsters, and cytodestructive changes in the culture of rat and mice embryonal cells and in cells of a transplantable line Vero. In terms of its properties it may be referred to human viruses of the Papova group. A combined action of DNA- and RNA-containing viruses produces a transformation effect on embryonal hamster cells and the cells of a transplantable line Vero.
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