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  • Title: Ultrastructure of human uterine epithelium at the time of implantation after postovulatory administration of norethindrone.
    Author: Nilsson O, Nygren KG.
    Journal: Ups J Med Sci; 1974; 79(2):65-71. PubMed ID: 4837833.
    Abstract:
    The impact of postovulatory norethindrone treatment upon the uterine epithelium of normal women at the time of implantation was studied in 7 women for a total of 11 menstrual cycles (3 cycles served as controls). A total of 150-300 mg norethindrone was administered orally for 2-4 days postovulation. Plasma progesterone, estradiol, and norethindrone levels were determined daily and an endometrial biopsy was obtained at the expected time of implantation of each cycle for light- and electron-microscopy studies. No consistent differences were revealed by light microscopy, however, electron microscopy revealed larger mitochondria and the presence of nucleolar channel systems after treatment, suggesting an increased progesteronelike influence in spite of the decrease in progesterone plasma levels. It suggested that these structural changes might change the functional properties and thereby impair normal implantation.
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