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  • Title: Comparison of the patterns of androstenedione, progesterone, and estradiol during the human menstrual cycle.
    Author: Ribeiro WO, Mishell DR, Thorneycroft IH.
    Journal: Am J Obstet Gynecol; 1974 Aug 15; 119(8):1026-32. PubMed ID: 4847439.
    Abstract:
    The pattern of androstenedione (A), serum estradiol (E2), and progesterone was measured during the menstrual cycle. No clear-cut pattern was observed for A such as was observed for E2 and progesterone. The mean levels of A tended to increase from Day 1 of menses to midcycle in all women, following the luteinizing hormone (LH) peak, but with marked fluctuation. A significant decline (p.05) in mean A levels from the LH peak to the day prior to menses was noted in all subjects. The ovaries secreted A throughout the menstrual cycle, with the lowest rate just prior to menses. The marked daily variation in A was most likely caused by the adrenal gland. Whether or not A has a luteal origin has not been resolved.
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