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  • Title: Subcutaneous ancrod therapy in peripheral arterial disease: improvement in blood viscosity and nutritional blood flow.
    Author: Lowe GD, Morrice JJ, Forbes CD, Prentice CR, Fulton AJ, Barbenel JC.
    Journal: Angiology; 1979 Sep; 30(9):594-9. PubMed ID: 484913.
    Abstract:
    Nine patients with extensive peripheral arterial disease were treated with subcutaneous injections of ancrod (Arvin) for 10 to 21 days. Reduction in plasma fibrinogen was associated with a sustained reduction in plasma and blood viscosity, and a sustained increase in nutritional skin blood flow, measured by a Xenon-133 clearance technique (P less than 0.001). These findings may be relevant to the therapeutic effect of ancrod in ischemic rest pain.
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