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  • Title: Effect of zinc and cadmium on guinea-pig complement.
    Author: Amiraian K, McKinney JA, Duchna L.
    Journal: Immunology; 1974 Jun; 26(6):1135-44. PubMed ID: 4851716.
    Abstract:
    Zinc, cadmium or nickel ion in the presence of optimum Ca+ + and Mg+ + will enhance the activity of guinea-pig complement in immune haemolysis. The range of optimum concentration of Zn+ + is 10-6–10-5 M and is influenced by the concentrations of sensitized erythrocytes (5–500 × 107) and guinea-pig complement. Enhancement by Zn+ + is unrelated to potentiation of guinea-pig complement activity by the zinc metalloenzyme, CPAγ. These cations may participate in a late-acting step of one of the pathways proposed for the interaction of guinea-pig complement with immune aggregates; or they may, at 37°, destroy an inhibitor of immune haemolysis.
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