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  • Title: Humoral and cellular aspects of immunoglobulin allotype suppression in the rabbit. II. Effect of beta locus suppression on immunoglobulin receptor-bearing lymphocytes.
    Author: Catty D, Chambers L, Lowe JA.
    Journal: Immunology; 1974 Feb; 26(2):331-43. PubMed ID: 4852313.
    Abstract:
    Rabbits born as b locus genotypic b4, 6 heterozygotes, but exposed in utero or neonatally to anti-b6 antibody, show chronic phenotypic suppression of the synthesis of the b6 allele in serum immunoglobulin. The suppression has been quantified over an extended period in relation to the synthesis of the alternative b locus allele (b4), a locus determinants, and total IgG. b locus suppression does not alter the synthesis or proportions of a locus (a1 and a3) determinants. The abrogation of suppression which can be effected neonatally by injection of immunoglobulin appears to be an antibody-neutralizing event since it requires specifically b6 determinants and cannot be achieved with non-b6 (5,9) complexes formed in vivo. Neutralization results in the rapid establishment of a b6 immunoglobulin-synthesizing cell population. Two assays, the mixed rosette and lymphocyte transformation tests with anti-allotype sera, have been used to examine the influence of suppression and suppression-neutralization on the distribution of allotypic determinants on immunoglobulin receptor bearing lymphocytes in the peripheral circulation and lymphoid tissues. In b6-suppressed rabbits there is an absence of b6-carrying lymphocytes in all the lymphoid tissues examined. In suppression-neutralized rabbits, however, such cells are present in numbers which correlate reasonably well with the proportion of b6 in the serum immunoglobulin. In rabbits in which no b6 was detectable at any time in the serum to 100 days of age, intensive immunization with b6 did not result in production of antibody to the b6 determinant. These findings are discussed in relation to proposals of the mechanism of induction and maintenance of chronic suppression in the rabbit.
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