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  • Title: Intravaginal PGE2 in early abortion.
    Author: Jones JR, Perez RJ.
    Journal: Prostaglandins; 1974 Jul 25; 7(2):149-63. PubMed ID: 4852554.
    Abstract:
    Intravaginal prostaglandin E2 (PGE2) was administered to 10 women in early (less than 50 days) pregnancy. Complete abortion was affected in 8, an incomplete abortion in 1, and 1 was a failure. Significant systemic side effects were noted in all subjects. Urinary hcG excretion rates prior to and on the 2nd and 14th day after PGE2 showed a decrease in all successfully aborted subjects and an initial decrease but a subsequent rise in the failure subject. Plasma concentrations of progesterone and estradiol-17 Beta showed no significant alterations during the early (less than 2 hours) administration of PGE2 but decreased significantly in all subjects just prior to expulsion, and at intervals thereafter. Estradiol-17Beta and progesterone alterations appeared to parallel each other indicating a common source, the corpus luteum. The mechanism by which PGE2 may effect early abortion is discussed.
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