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  • Title: Fast neutron and x-ray induced single strand DNA breaks in cultured mammalian cells.
    Author: Moss AJ, Baker ML, Prior RM, Erichsen EA, Nagle WA, Dalrymple GV.
    Journal: Radiology; 1976 May; 119(2):459-61. PubMed ID: 4853.
    Abstract:
    The relative biologic effectiveness (RBE) of fast neutrons in the production of single strand DNA breaks is 1.6 as compared to that of 250 kVp x rays. Monolayers of L-929 cells were treated with dinitrophenol during irradiation to prevent the DNA strands from rejoining; the extent of DNA damage was measured by the alkaline sucrose sedimentation method. The RBE for DNA damage is essentially the same as the RBE measured by cell survival methods.
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