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  • Title: Phenytoin inhibition of parathyroid hormone induced bone resorption in vitro.
    Author: Harris M, Jenkins MV, Wills MR.
    Journal: Br J Pharmacol; 1974 Mar; 50(3):405-8. PubMed ID: 4853617.
    Abstract:
    1 A study is reported of the effects of phenytoin and phenobarbitone on bone calcium mobilization by parathyroid hormone in vitro.2 In a therapeutic concentration (15 mug/ml), phenytoin significantly inhibited parathyroid hormone-induced calcium release from bone.3 The inhibitory effect of phenytoin on bone calcium mobilization could play a role in the maintenance of hypocalcaemia in epileptic patients on long-term anticonvulsant drug therapy.
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