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  • Title: Inhibition of prostaglandin biosynthesis by sulphasalazine and its metabolites.
    Author: Collier HO, Francis AA, McDonald-Gibson WJ, Saeed SA.
    Journal: Prostaglandins; 1976 Feb; 11(2):219-25. PubMed ID: 4854.
    Abstract:
    Sulphasalazine (SZ) inhibits prostaglandin (PG) biosynthesis in vitro with a potency comparable to that of aceylsalicylate. The metabolites of SZ, sulphapyridine and 5-aminosalicylic acid, were of considerably lower potency as inhibitors of PG biosynthesis in the synthetase preparations used. Th inhibition of prostaglandin production by SZ could at least partly account for the clinical utility of sulphasalazine in ulcerative colitis. Sulphapyridine may help to maintain inhibitory concentrations of SZ by restraining bacterial breakdown of the active drug.
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