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  • Title: [Degree of maturity and histogenesis of stomach cancer and their importance for prognosis].
    Author: Dikshteĭn EA, Vasilenko IV, Shevchenko NI, Merezhko VA.
    Journal: Arkh Patol; 1979; 41(7):25-32. PubMed ID: 485873.
    Abstract:
    The intensity of differentiation of adenocarcinoma and non-differentiated cancer cells was studied histochemically and electron microscopically. A higher ratio of nucleus volume to cytoplasm volume and nucleus nuclei acids to cytoplasm RNA, low secretory activity in adenocarcinoma cells as compared to nondifferentiated cancers were found. Adenocarcinomas were shown to have a higher activity of NADP-dependent dehydrogenases, more numerous free ribosomes as compared to nondifferentiated carcinoma. This suggests a lower degree of cell differentiation and high proliferative activity in adenocarcinomas than in nondifferentiated carcinoma. Differences in the intensity of cell and tissue differentiation in adenocarcinomas and nondifferentiated carcinoma and due to differences in their histogenesis and must be taken into account in evaluations of the prognosis.
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