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  • Title: Influence of thyroid state and improved hypoxia tolerance on noise-induced cochlea damage.
    Author: Berndt H, Wagner H.
    Journal: Arch Otorhinolaryngol; 1979; 224(1-2):125-8. PubMed ID: 485939.
    Abstract:
    Guinea pigs were exposed to pure tone noise (2.7 kHz, 130 dB, 1 h) and cochlear microphonic potentials were measured 24 h after exposure. There is the possibility to modify the resulting noise-induced cochlea damage by regulating the function of the thyroid gland to alter the rate of metabolism. A hypofunction of the thyroid gland during sound exposure lessens, an over-function aggravates the damage. After gradual adaptation of the animals to a simulated 10,000 m altitude, the electrophysiologically demonstratable noise-induced damage was reduced. This might be explained by the greater hypoxia tolerance and perhaps additional better oxygen supply to the receptor cells.
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