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  • Title: Lipid packing and transbilayer asymmetries of mixed lipid vesicles.
    Author: Carnie S, Israelachvili JN, Pailthorpe BA.
    Journal: Biochim Biophys Acta; 1979 Jul 05; 554(2):340-57. PubMed ID: 486446.
    Abstract:
    Predictions, based on a previously developed theory, of the radii and asymmetric lipid distribution of mixed phosphatidylcholine/lysophosphatidylcholine and phosphatidylcholine/cholesterol vesicles of variable composition are presented. The results compare well with available experimental data, except for cis-unsaturated phosphatidylcholine/cholesterol vesicles at high concentrations of cholesterol. It is concluded that specific lipid-lipid interactions need not be invoked for saturated and trans-unsaturated phosphatidylcholine mixed with lysophosphatidylcholine or cholesterol. A discussion of the effect of packing stresses on induced flip-flop and non-spherical vesicles is also presented.
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