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  • Title: Humoral regulation of pluripotent stem cell differentiation.
    Author: Frindel E.
    Journal: Biomedicine; 1979 Jul; 31(4):113-7. PubMed ID: 486689.
    Abstract:
    Humoral regulators of CFU-S differentiation have been demonstrated in bone marrow of Ara-C treated animals. These factors are effective in vivo and are also capable of inducing erythropoietic differentiation of normal CFU-S in vitro. These results seem to indicate that the microenvironment acts at the committed stem cell level while the factors described in this paper act on the pluripotent stem cells.
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