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  • Title: Ribonucleic acid synthesis in T2-infected Escherichia coli during "stringent" control.
    Author: Sharp K, Green MH.
    Journal: J Bacteriol; 1968 Jul; 96(1):111-6. PubMed ID: 4874300.
    Abstract:
    The leucine auxotroph Escherichia coli 2961 exhibited stringent control of net ribonucleic acid (RNA) synthesis during amino acid starvation. After leucine was exhausted from the medium, the rate of uracil incorporation into RNA rapidly decreased to 2 to 4% of the prestarvation value. Infection of the starved cells with T2 phage stimulated uracil incorporation to a level equivalent to that of unstarved, T2-infected cells. The RNA synthesized during leucine starvation of the T2-infected cells consisted of T2 and E. coli messenger RNA, but stable ribosomal RNA (23S and 16S) did not appear to be synthesized. It is concluded that one or more T2-specific proteins are required to shut off host messenger RNA synthesis. Furthermore, transcription of E. coli and T2 deoxyribonucleic acid is not necessarily coupled to the translation of messenger RNA during stringent control of net RNA synthesis.
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