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  • Title: The hormonal and immunological status of vasectomised men.
    Author: Tyler JP, Richardson DW, Newton JR.
    Journal: Contraception; 1979 Jun; 19(6):599-611. PubMed ID: 487810.
    Abstract:
    The concentration of FSH, LH, testosterone and sperm agglutinating and cytotoxic antibodies have been determined in 87 men at varying time intervals after vasectomy. The results indicated that vasectomy is not associated with statistically significant changes in any of these parameters. Furthermore, no correlation existed between the development of sperm antibodies and the peripheral endocrine status of an individual. The study assessed, in the same individual, concentrations of follicle stimulating hormone (FSH), luteinizing hormone (LH), testosterone (T), and sperm agglutinating and cytotoxic antibodies before, and at varying time intervals, after vasectomy and examined the relationship between the sperm antibody and endocrine status of vasectomized men. Hormonal values for men at different times after vasectomy were (in units/liter): FSH, 1.78, 1.55, and 1.80 at pre- and 3-month and 4 month postoperative intervals, respectively; for LH, 3.6, 3.54, and 3.81, respectively; for T, .3/19, 14.41, and 13.44, respectively; and for semen T, 1.61, 1.33, and 1.41. Values of T in 10 subjects followed for 3 years were: 16.35 at 3 months, 17.74 at 4 months, and 17.22 at 3 years. None of these changes was statistically significant. Before vasectomy, none of the 72 subjects had spermocytotoxic antibodies; after the operation 6 subjects (8%) developed these antibodies, and another 5 (7%) gave a weakly positive reaction; only 1/10 evaluated in 3-year follow-up was positive. Sperm agglutinating antibodies were found in 4 men (6%) before vasectomy; 14 of the other 68 (21%) developed these antibodies after vasectomy. 6/10 in the 3-year follow-up showed sperm agglutinins. No statistically significant differences were found between the preand postvasectomy values for LH, FSH, and T in the 8 subjects who developed spermocytotoxic antibodies, nor were the mean values for this group significantly different. Similarly, hormonal values from the group of 11 men who developed or increased their titer of sperm agglutinins were not statistically different from men who did not develop them.
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