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  • Title: [Antitumor and immunodepressive action of dexamethasone on a leukemia L-1210 model].
    Author: Berezina TA, Uteshev BS, Babichev VS.
    Journal: Farmakol Toksikol; 1979; 42(5):537-41. PubMed ID: 488332.
    Abstract:
    The effect of single administration of dexamethason in doses of 10, 20, 50 and 100 mg/kg on the spleen content of lymphomic colonies, normal colony-forming units and antibody-forming cells was studied in experiments on CBA and DBA/2 mice with transplanted leukemia L-1210. It has bear dependence on the dosage, the immunodepressant action of the drug being more pronounced in CBA mice as compared to DBA/2 mice with leukemia L-1210. The immunodepressant activity of dexamethason is approximately equal to the antineoplasic one. Single administration of the drug has practically no effect on hemopoiesis.
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