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  • Title: Strain differences in the immune response of mice. II. Responses by neonatal cells in irradiated adult hosts.
    Author: Playfair JH.
    Journal: Immunology; 1968 Dec; 15(6):815-26. PubMed ID: 4884962.
    Abstract:
    Lethally irradiated NZB and C57BL mice were injected with syngeneic thymus and marrow, or thymus and liver cells, and immunized with sheep red blood cells (SRBC). As in intact neonatal mice, NZB plaque-forming cell (PFC) responses were significantly higher than C57BL. Irradiated (NZB×C57BL)F1 and (NZB×BALB/c)F1 hybrid mice were given mixtures of parental and syngeneic cells, and it was shown that the high NZB response to SRBC was characteristic of the newborn liver rather than of the thymus. NZB liver gave rise to more PFC against SRBC than BALB/c liver, but not more against chicken RBC. It is argued that liver cells contain genetic information regarding antibody specificity. C57BL cells grew poorly in F1 hosts, but the low SRBC response appeared to be characteristic of both liver and thymus. The nomenclature of the participating cells, and their role in the development of immunological responsiveness, are discussed.
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