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  • Title: Mutations of Chinese hamster somatic cells from 2-deoxygalactose sensitivity to resistance.
    Author: Claverie JM, de Souza AC, Thirion JP.
    Journal: Genetics; 1979 Jun; 92(2):563-72. PubMed ID: 488705.
    Abstract:
    In Chinese hamster somatic cells, the spontaneous change of phenotype from 2-deoxygalactose sensitivity to resistance was studied using fluctuation test experiments à la Luria and Delbrück (1943) for four Chinese hamster cell strains derived from V79. The results are consistent with true mutational events. The mutation rates are in the range of 1 to 3.5 X 10(-5) per cell per generation. The relationship between the 2-deoxyglactose resistance and the galactokinase markers is discussed.
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