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  • Title: [The pressure reducing effects of pilocarpin in combination with Dipivalyl-epinephrine in glaucoma simplex (author's transl)].
    Author: Krieglstein GK, Leydhecker W.
    Journal: Klin Monbl Augenheilkd; 1979 Jul; 175(1):86-90. PubMed ID: 491472.
    Abstract:
    We compared in two controlled studies the effect of pilocarpine 1% with the effect of pilocarpine 1% combined with 0,05% or 0,1% dipivalyl-epinephrine in patients with open-angle glaucoma. The pressure reducing effect of pilocarpine 1% was significantly increased and prolonged by the combination with dipivalyl-epinephrine. 0,1% dipivalyl-epinephrine + pilocarpine 1% did not have a more significant pressure reducing effect in our patients than 0,05% dipivalyl-epinephrine + pilocarpine 1%, but the reduction of pressure persisted longer. It is a considerable advantage in glaucoma therapy to diminish or to avoid systemic and local side effects of epinephrine due to very low concentrations of dipivalyl-epinephrine.
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