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  • Title: Tuberculin-active carbohydrate that induces inhibition of macrophage migration but not lymphocyte transformation.
    Author: Chaparas SD, Thor DE, Godfrey HP, Baer H, Hedrick SR.
    Journal: Science; 1970 Nov 06; 170(3958):637-9. PubMed ID: 4919183.
    Abstract:
    A tuberculin carbohydrate fraction, GAE, in sensitized animals induced a delayed type of skin reactivity and inhibited the migration of macrophages but failed to stimulate lymphocyte transformation in vitro. Tuberculin protein-containing fractions were active in each test. These results show that in vitro lymphocyte transformation is not necessarily a corollary of delayed type hypersensitivity.
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