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  • Title: Validity of plasma factor in schizophrenia as measured by tryptophan uptake.
    Author: Guchhait RB, Janson C, Price WH.
    Journal: Biol Psychiatry; 1975 Jun; 10(3):303-14. PubMed ID: 49200.
    Abstract:
    The uptake of L-tryptophan by chicken erythrocytes is stimulated by the presence of human plasma; however, there is no difference between the stimulation caused by plasmas of normal, chronic hospitalized nonschizophrenic, or chronic hospitalized schizophrenic subjects. Human plasma in general contains a complement-dependent antibody which reacts with an antigen present in the membrane of chicken erythrocytes resulting in hemolysis. Hemolysis can be maintained at a constant level by certain concentrations of Ca++ ion, the addition of which resulted in a gradual increase in tryptophan uptake. The calcium effect is probably due to the fact that the metal acts as a cofactor or modifier of component(s) of plasma causing higher uptake. The data indicate that hemolysis is not determining uptake of tryptophan by chicken erythrocytes.
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