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  • Title: Capsid size and deoxyribonucleic acid length: the petite variant of bacteriophage T4.
    Author: Eiserling FA, Geiduschek EP, Epstein RH, Metter EJ.
    Journal: J Virol; 1970 Dec; 6(6):865-76. PubMed ID: 4924630.
    Abstract:
    A mutant which produces a small-headed ("petite") variant of bacteriophage T4 is described. The mutation (E920g) maps in a new gene (66) between genes 23 and 24. Petite phage particles composed up to 70% of the phage yield. The petite phage was nonviable upon single infection but produced progeny when two or more infected a cell. Its genome was shortened by a random deletion of about 30%, and deoxyribonucleic acid (DNA) extracted from the particles was 0.68 the length of normal T4 DNA. The reduction in DNA length was accompanied by a proportional reduction in head volume. Double mutants between E920g and head-defective mutants in gene 21 produced unusually high frequencies of spherical capsidlike structures (tau-particles).
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