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  • Title: Dose-response relationship of luteinizing hormone to luteinizing hormone--releasing hormone in man.
    Author: Kastin AJ, Schally AV, Gual C, Midgley AR, Miller MC, Cabez A.
    Journal: J Clin Invest; 1971 Jul; 50(7):1551-3. PubMed ID: 4932985.
    Abstract:
    In previous clinical studies with highly purified porcine luteinizing hormone-releasing hormone (LH-RH), administration of the somewhat arbitrarily chosen doses of 700-1500 mug resulted in increased serum levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). The present study determined the minimum effective dose as well as the relationship of the response of serum LH and FSH to the dose of LH-RH administered. Three normal men received i.v. injections of 1.1-810 mug of LH-RH. A dose of 10 mug of LH-RH caused a statistically significant elevation in serum LH. 30 mug of LH-RH significantly increased serum FSH levels. A highly significant linear trend was observed in the log dose-response curve. The results indicate that both LH and FSH release occurs in man with doses of LH-RH much lower than previously used and that a linear log dose-response relationship can be obtained.
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